CHARACTERIZATION OF MANGIFERA INDICA LINN (FAMILY: ANACARDIACEAE.) SEED ENDOSPERM GUM FOR POTENTIAL APPLICATION AS PHARMACEUTICAL EXCIPIENT.
Abstract
Natural products are increasingly used as excipients in formulation systems over the synthetics because of their comparative advantages. This study was aimed at the characterization of Mangifera indica seed gum (MisG) extracted from its endosperm using microwave-assisted technique. Physiochemical, pharmacognostic, microbial load were carried out using established methods and standard protocols. The yield of MisG was 15.63 0.05% w/w. Physicochemical analysis revealed that MisG had particle size of 115.00 0.12 ?m, moisture content of 10.15 0.11%, pH of 6.20 0.03, swelling index of 2.27 0.09, water binding capacity 112.0 0.1%, viscosity of 1.1 0.2cP, flow rate of 3.01 0.09 g/sec, bulk density of 0.51 0.01 g/cm3, tapped density of 0.63 0.01 g/cm3, Hausners ratio of 1.230.03, compressibility index of 19.10 0.03 and angle of repose of 29.35. Microbial evaluation revealed the absence of objectionable microorganisms while the total aerobic microbial and yeast and mould counts were 1.20x102 and 11.50 x101 respectively. These values did not exceed the microbial limits specified by the United States Pharmacopoeia. These desirable physicochemical, pharmacognostical and microbial properties suggest that MisG could have good excipient potentials in pharmaceutical formulations.
