COMPARISON OF ESTIMATED GLOMERULAR FILTRATION RATE (eGFR) USING SERUM CREATININE AND CYSTATIN C IN APPARENTLY HEALTHY INDIVIDUALS

Abstract

SEVERAL STUDIES HAVE SHOWN THE LIMITATIONS OF CREATININE IN THE DETECTION OF EARLY CHANGES IN GLOMERULAR FILTRATION RATE (GFR). MEASUREMENT OF SERUM CYSTATIN C HAS BEEN PROPOSED IN ASSESSMENT OF RENAL STATUS IN ORDER TO IMPROVE MANAGEMENT. THE AIM OF THIS STUDY WAS TO COMPARE THE ESTIMATED GLOMERULAR RATE GFR (eGFR) CREATININE AND eGFR CYSTATIN C AMONG APPARENTLY HEALTHY INDIVIDUALS WITH A VIEW TO ESTABLISHING THE PARAMETER THAT WILL DETECT THE CLINICALLY SIGNIFICANT LEVEL eGFR<60ML/MM/1.73M² FIRST. A TOTAL OF 100 MALE WITH A MEAN AGE 46.5 YEARS (1.15) WERE RECRUITED FOR THIS STUDY. SERUM CYSTATIN C AND CREATININE WERE ASSAYED USING THE IMMUNOTURBIDOMETRIC AND KINETIC MODIFIED JAFFÉ’S METHOD (TRACEABLE TO IDMS) RESPECTIVELY. PEARSON CORRELATION AND BLAND-ALTMAN PLOT WERE USED FOR COMPARISON. THE MEAN EGFR FOR SERUM CYSTATIN C WAS 96.5 ML/MM/1.73M318.18 AND MEAN EGFR CREATININE WAS 96.8 ML/MM/1.73M3 22.39. THE EGFR USING SERUM CYSTATIN C HAS SIGNIFICANT POSITIVE CORRELATION WITH EGFR USING SERUM CREATININE (R=0.671; P=0.000). THE EGFR USING SERUM CYSTATIN C REVEALED THAT 3% OF THE PARTICIPANTS SHOWED REDUCED RENAL FUNCTION BASED ON THE GROUPING OF KIDNEY DISEASE BY THE KIDNEY DISEASE: IMPROVING GLOBAL OUTCOMES (KDIGO) CLASSIFICATION BUT THIS WAS NOT DETECTED BY SERUM CREATININE METHOD. THERE WAS AGREEMENT BETWEEN THE EGFR CREATININE AND EGFR CYSTATIN C (97% OF THE PLOT FELL WITHIN 2SD). CONCLUSION: EGFR CYSTATIN C SHOWED EARLY STAGE OF REDUCED RENAL FUNCTION NOT DETECTED BY EGFR CREATININE.